Medical Co-morbidities in ASD

Featuring Shafali Jeste M.D. - 11/27/2018

Individuals with autism spectrum disorder (ASD) often have co-occurring medical conditions such as epilepsy, insomnia, psychiatric conditions, and gastro-intestinal issues. Epilepsy occurs in approximately 20% of individuals with ASD over the lifespan. Insomnia is also common in individuals with ASD. Up to 80% of children with ASD experience sleep disturbance, including difficulty getting to sleep, frequent night awakenings, early morning awakenings, decreased need for sleep, and daytime sleepiness and irritability. In addition, psychiatric comorbidities, such as ADHD, anxiety, and depression, occur more frequently in individuals with ASD than in typically developing individuals. Lastly, individuals with ASD are more likely to experience gastrointestinal problems such as chronic constipation, diarrhea, irritable bowel conditions, reflux, and food intolerances and allergies. Due to increased prevalence rates, it is important providers screen for medical comorbidities in individuals with ASD.

Dr. Jeste is an Associate Professor in Psychiatry and Neurology in the UCLA David Geffen School of Medicine and a lead investigator within the UCLA Center for Autism Research and Treatment (CART). She is a behavioral child neurologist specializing in autism and related neurodevelopmental disorders and directs the Care and Research in Neurogenetics (CARING) Clinic at UCLA. Dr. Jeste’s research is focused on the use of novel electrophysiological biomarkers to better define early predictors of autism spectrum disorder (ASD) and to define more homogeneous, brain-based subgroups within the autism spectrum in order to inform treatment targets. Dr. Jeste serves as the UCLA site director for a multisite National Institutes of Health Autism Biomarkers Consortium for Clinical Trials research study. She has received numerous awards for her research and published more than 50 peer-reviewed articles. Additionally, she serves on the board of directors for the Child Neurology Foundation and was elected to serve on the board of directors for the International Society for Autism Research.

What We Learned

  • Medical comorbidities are common in individuals with ASD. Such comorbidities include epilepsy, sleep impairment, psychiatric conditions, and gastrointestinal issues.
  • Genetic testing is highly recommended and should be part of the routine medical workup for individuals with ASD. Genetic testing should be followed up with genetic counseling as soon as possible to decrease the time gap in between.
  • Seizures are more prevalent in children with ASD, especially during adolescence, but electroencephalogram (EEG) is only recommended if there is a clinical concern or high risk category.
  • All children with ASD should be screened for sleep disturbance. Behavioral management, such as strict bedtime routines, can be used to decrease negative behaviors, which could stem from insomnia. If sleep issues persist, parents should then seek a specialist for guidance.

Assessment and Intervention for Food Selectivity

Featuring Mitch Fryling, Ph.D., BCBA-D - 10/11/2018

Mealtimes are meant to be enjoyable and satisfying experiences for families. However, for parents of children with autism spectrum disorder (ASD), mealtimes can be extremely frustrating and stressful times. Feeding problems are very common in children with ASD and occur in up to 90% of children with ASD (Kodak & Piazza, 2008). Furthermore, approximately 70% of children with ASD are considered “selective eaters” (Twachtman-Reilly et al., 2008). In collaboration with the family’s other providers (e.g., pediatrician, speech and language therapist, gastroenterologist), behavioral strategies based on principles of applied behavioral analysis (ABA) are often implemented to improve feeding behaviors and broaden a child’s diet.

Dr. Mitch Fryling is an Assistant Professor in the Applied Behavior Analysis Graduate Program at California State University, Los Angeles. He received his B.S. and M.A. in psychology (behavior analysis) from Western Michigan University in Kalamazoo, Michigan and his Ph.D. in psychology (behavior analysis) from the University of Nevada, Reno. His primary scholarly interests are in the area of behavioral theory and philosophy with a particular focus on social behavior and interbehavioral psychology. He is also interested in feeding issues and the relationship between theory and application. Dr. Fryling has published his work in a variety of journals, serves as Editor in Chief of the Psychological Record and is co-editing a textbook, Applied Behavior Analysis of Language and Cognition.

What We Learned

  • Having an interdisciplinary team is essential for assessing and treating feeding problems. A team of specialists (e.g., medical, behavioral, nutritional, occupational, speech and language) is needed to ethically and safely address feeding problems in children with ASD.
  • Three common behavioral strategies utilized for feeding problems are noncontingent reinforcement, differential reinforcement of alternative behavior, and stimulus fading.
  • Challenging behaviors often impact progress and need to be addressed when implementing a treatment plan for feeding problems.

Summer Training Workshop for Preschool Educators - July 2018

The two-day training workshop was for Preschool Special Education and General Education Teachers, Teaching Assistants, Behavior Interventionists, Speech and Language Pathologists, Occupational Therapists and School Psychologists from local school districts. The workshop included demonstrations, guided observation, behavioral rehearsal activities to practice new skills, interactive instruction, handouts outlining new skills, and an overview of the research underlining the content. Attendees became familiar with developing and assessing play skills; utilizing strategies for challenging behaviors in the classroom; and assessing social communication.

Optimizing Social Engagement and Developmental Outcomes in Young Children with Autism

Featuring Ty Vernon, Ph.D. - 06/24/18

Naturalistic Developmental Behavioral Interventions (NDBIs) are a type of applied behavior analysis (ABA) that incorporate learning opportunities into a child and family’s existing daily routines. Skills and treatment goals are based on developmentally appropriate expectations and focus on key areas of development like social engagement. Pivotal Response Training (PRT) is one of several NDBI treatments that is available to the community. PRT is a research-based intervention for individuals with Autism Spectrum Disorder (ASD) developed by Drs. Robert and Lynn Koegel at the University of California Santa Barbara. PRT targets pivotal areas of a child’s development, such as motivation, responsivity to multiple cues, self-management, and social initiations. By targeting these critical areas, PRT results in widespread, collateral improvements in other social, communicative, and behavioral areas that are not specifically targeted. Key aspects of PRT include child choice, task variation, interspersing maintenance tasks, rewarding attempts, and the use of direct and natural reinforcers. PRT is used to teach language, decrease disruptive/self-stimulatory behaviors, and increase social, communication, and academic skills.

Ty Vernon is an Assistant Professor of Clinical Psychology within the Department of Counseling, Clinical, & School Psychology and Director of the Koegel Autism Center at UCSB. His primary research interests include identifying novel methods for measuring, understanding, and altering the social developmental trajectories of children and adults with autism.

Dr. Vernon has participated in the empirical investigation of several innovative social interventions, including an early social engagement paradigm for toddlers and their parents, group social skills interventions for school-aged children and adolescents, and vocational training programs for young adults with ASD. He concurrently serves as the Director of the Koegel Autism Center Assessment Clinic, which serves as a clinical and research hub for the detection and treatment of autism-related symptomatology in toddlers, children, adolescents, and adults.

What We Learned

  • PRT is a naturalistic intervention model derived from Applied Behavior Analysis (ABA). PRT was created by Drs. Robert and Lynn Koegel, and research over the past 30 years supports its effectiveness in individuals with ASD.
  • PRT targets pivotal areas of a child’s development, such as motivation, self-management, and social initiations. By targeting these critical areas, PRT results in widespread, collateral improvements in other social, communicative, and behavioral areas that are not specifically targeted.
  • PRT intervention strategies include child choice, task variation, interspersing maintenance tasks, rewarding attempts, and the use of direct and natural reinforcers.

Complementary and Alternative Treatments in ASD: Fact or Fiction?

Featuring James McCracken, MD - 05/24/18

Research over the last 40 years has identified some evidence-based treatments for individuals with autism spectrum disorder (ASD). Among available treatments for individuals with ASD, applied behavior analysis (ABA) has the most evidence supporting its effectiveness. In addition to ABA, other naturalistic developmental behavioral interventions (NDBIs) have gained evidence for treating core deficits in ASD (Schreibman et al 2015). Despite the growing evidence-base for the effectiveness of behavioral interventions, the use of complementary and alternative treatments (e.g., the gluten-free casein-free diet, supplements, chelation, secretin, melatonin) that lack empirical support continues to be widespread (Golnik and Ireland 2009). Previous studies estimate that 52% - 95% of children with ASD are treated with complementary and alternative treatments (Harrington et al. 2006, Wong and Smith 2006; Hanson et al 2007). It is important to review the evidence-base for commonly utilized treatments so that clinicians can communicate potential benefits and risks to families.

Dr. James McCracken is the Joseph Campbell Chair in Child Psychiatry and Director of the Division of Child and Adolescent Psychiatry at the David Geffen School of Medicine at UCLA. He is recognized as a leading authority on the testing of new treatments for children, adolescents, and adults with autism spectrum disorder (ASD) and related conditions, such as attention-deficit/hyperactivity disorder, anxiety, and cognitive disorders. He is the Founder and Director of the UCLA Child and Adult Neurodevelopmental (CAN) Clinic, UCLA’s Center for Autism Research and Treatment’s primary clinical service for individuals of all ages with ASD. Dr. McCracken’s research includes examining the combination of medical treatments to enhance the effects of behavioral and cognitive interventions, and the testing of other new pharmacologic and cognitive treatments for a variety of neuropsychiatric disorders in children. Dr. McCracken has received numerous awards for his research, published more than 300 papers and chapters in the area of child psychiatry, and serves on the editorial board of the journal Molecular Autism.

What We Learned

  • Complementary and alternative medicine (CAM) is the popular term for health and wellness therapies that have typically not been part of conventional western medicine.
  • Despite a lack of evidence demonstrating their effectiveness CAMs are commonly used to treat autism spectrum disorder (ASD).
  • While there are no established CAM treatments for ASD, there are some promising leads. The safety of CAMs treatments should always be a primary concern when considering their use.
  • To learn more, the following article is recommended: Levy, S.E. & Hyman, S.L. (2015). Complementary and alternative treatments for children with autism spectrum disorders. Child and Adolescent Clinics of North America, 24, 117-143.

thinkSMART: How to Target Executive Functioning Skills in Youth

Featuring Alissa Ellis, Ph.D. - 3/22/18

Executive functioning skills are brain processes that help people plan, organize, maintain attention, and multitask. Strong executive functioning has been related to success in school, jobs, and relationships, as well, to improved mental and physical health and overall quality of life. Weak executive functioning in childhood predicts weak executive functioning in adulthood. As such, if the foundation for these skills is not solidly constructed in childhood, they are not likely to improve into adulthood. Executive functioning in adolescence has been related to self-reliance, strong identity development, and work orientation (Galambos et al. 2005). This suggests that youth with solid executive functioning skills can approach their lives in a strategic, flexible, and efficient manner and be more likely to develop a stronger, more independent sense of self.

Executive functions seem straightforward when defined, but understanding how weaknesses in executive functions translate into daily behaviors can be less clear. Often, parents realize that they are frustrated with their teen for their approach to tasks and responsibilities, but aren’t sure why there are problems. Weaknesses in day-to-day executive functioning skills may underlie many of these frustrations.

Dr. Ellis is a clinical neuropsychologist with expertise in psychodiagnostics and treatment for children, adolescents and adults with mood disorders, anxiety disorders, and ADHD. She is currently an Assistant Clinical Professor in the Department of Psychiatry at the Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA. Dr. Ellis is the founder of the thinkSMART® program, a novel treatment for weaknesses in executive functioning. The thinkSMART™ program was born out of Dr. Ellis’ frustration with the lack of effective, non-medication interventions for youth with executive dysfunction, particularly (but not limited to) individuals with ADHD. In addition to being the Director of the thinkSMART ™ program, she works as an attending psychologist in the Child and Adolescent Mood Disorders Program (CHAMP).

What We Learned

  • Executive functions are the control functions needed for a person to accomplish and maintain goal directed activities. Executive functioning difficulties are universal but especially common in individuals with autism spectrum disorder (ASD).
  • Individuals with ASD often have executive functioning weaknesses in the areas of planning, problem solving, and cognitive flexibility.
  • The thinkSMART program is an intervention unique to UCLA that specifically targets executive functioning deficits by teaching concrete behavioral strategies (e.g., planner use, time management, sleep hygiene) to adolescents and their parents.
  • Unstuck & On Target (Kenworth et al., 2013) is an evidence-based curriculum to improve flexibility, goal setting and planning, and problem solving in children with autism spectrum disorder (ASD).

Measuring Change in Autism Spectrum Disorder

Featuring Catherine Lord, Ph.D. - 01/11/18

Research over the last 40 years has identified many intervention approaches for the treatment of autism spectrum disorder (ASD). A huge barrier in the field, however, has been the development of sensitive measures that accurately assess changes in ASD symptoms in response to intervention. While specific behavioral goals are commonly tracked throughout treatment, core social communication behaviors are infrequently measured and tracked at pre and post interventions in the community and educational settings. Dr. Catherine Lord developed the two gold standard diagnostic measures for ASD and recently developed a brief measure of treatment response for social communication behaviors in individuals with ASD. This activity informed learners on the importance of measuring change in individuals with ASD and specific ways clinicians can assess for change in individuals with ASD.

Dr. Lord is a Professor of Psychology in Psychiatry and founding Director of the Center for Autism and Developing Brain (CADB), at New York-Presbyterian Hospital, Weill Cornell Medicine, Columbia University College of Physicians and Surgeons. Dr. Lord is also a licensed clinical psychologist with specialties in diagnosis, social and communication development and intervention in autism spectrum disorders (ASD). She is renowned for her work in longitudinal studies of children with autism as well as for her role in developing the autism diagnostic instruments used in both practice and research worldwide. 

What We Learned

  • The Brief Observation of Social Communication – Change (BOSC – C; Grzadzinski, Carr, Colombi, Mcguire, Dufek, Pickles, & Lord, 2016), is a sensitive measure of social communication behaviors that can be used to monitor changes in ASD symptoms over time.
  • Measuring changes in ASD is essential for tracking treatment progress and setting long term goals for children with ASD.
  • Parents are an integral part of a child’s overall treatment program. Parent participation in treatment predicts better outcomes for children.